With the gang spread across the country (and beyond) at college, Spencer is back to feeling out of place, even when he returns home over winter break. Desperate to escape his grandfather who is sharing his room, and to feel confident again, he attempts to fix the broken Jumanji video game, giving his friends no choice but to level up and return to rescue him.

Ever since hulking lawman Hobbs, a loyal agent of America's Diplomatic Security Service, and lawless outcast Shaw, a former British military elite operative, first faced off, the duo have swapped smack talk and body blows as they've tried to take each other down. But when anarchist Brixton gains control of an insidious bio-threat that could alter humanity forever, these two sworn enemies will have to partner up to bring down the only guy who might...